The Relationship between Obesity-Related Factors and Graves' Orbitopathy

Background/Objectives: The aim of this study was to investigate whether there are relationships between obesity-related factors including body mass index (BMI), diabetes or prediabetes, hyperlipidemia, fasting plasma glucose, fasting plasma insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR), and high sensitive C-reactive protein (hs-CRP) and Graves’ orbitopathy (GO).

Subjects/Methods: Eighty-four patients with Graves’ disease (GD) (42 without GO and 42 with GO) were enrolled in this Cross-sectional cohort study. Sex, age, GD treatment history, height, body weight, waist circumference, smoking status, co-morbidities, and levels of free thyroxin, thyroid-stimulating hormone, thyroid-stimulating hormone receptor (TSHR) antibodies, fasting plasma glucose and insulin, and hs-CRP were recorded. Eye condition was evaluated using the NOSPECS classification and clinical activity score.

Results: BMI, fasting plasma insulin, and HOMA-IR were associated with the pres...