ASNA1 Is Essential for Cardiac Development and Function by Regulating Tail-Anchored Protein Stability and Vesicular Transport in Cardiomyocytes

We generated both constitutive and inducible cardiomyocyte-specific Asna1 knockout mouse models to study the ASNA1 function in cardiomyocytes and the molecular mechanisms underlying ASNA1-related cardiomyopathy.