DNA methylation and gene expression data for human senile lentigines

Description: This dataset contains the processed genomic and transcriptomic data generated in the study "Disrupted epigenetic regulation in human senile lentigines revealed by characterizing gene expression and DNA methylation alterations" (Clinical Epigenetics, under review).
Sample Information: Data were obtained from five individuals with senile lentigines (SL). For each subject, both senile lentigines (labeled "A") and adjacent non-lesional skin (labeled "B") were collected (Total n=10 samples).
Data Overview & Column Descriptions:
DNA_methylation.tsv.gz Genome-wide DNA methylation profiles derived from Whole Genome Bisulfite Sequencing (WGBS).chr: Chromosome number.pos: Genomic position of the CpG site (GRCh38).1A–5B: DNA methylation levels for each sample.gene_expression.tsv.gz Gene expression matrix derived from RNA-seq.gene_id: Ensembl gene identifier.transcript_id(s): Associated Ensembl transcript identifier(s).1A–5B: Expression levels in TPM (Transcripts Per Million).DMR_results.tsv Results of the differential methylation analysis.chr, start, end: Genomic coordinates of the DMR.cluster, n, width, invdensity, areaStat, maxStat, meanDiff: Standard output metrics from dmrFinder.groupA.mean / groupB.mean: Mean methylation levels for Group A (SL) and Group B (Non-SL).direction: Methylation status in SL (Hyper or Hypo).geneChr, geneStart, geneEnd, geneID, geneSymbol, gene_biotype: Genomic coordinates and metadata for the annotated nearest or overlapping gene.DEG_results.tsv Results of the differential expression analysis.ensembl_gene_id, hgnc_symbol: Gene identifiers.gene_biotype: Biological classification of the gene.medianCPM: Median Counts Per Million across samples.meanA / sdA: Mean and standard deviation of expression in SL (Group A).meanB / sdB: Mean and standard deviation of expression in non-lesional skin (Group B).logFC: Log2 fold change (SL / Non-SL).pvalue: Raw p-value derived from the t-test.