PCB exposure in adult male mice reduces proliferating cells in the prostate but minimally alters voiding

We test whether PCB exposure in adulthood alters voiding or prostate morphology in male mice. C57Bl/6J adult male mice were exposed to the human-relevant MARBLES PCB mixture (0, 0.1, 1, and 6 mg/kg/d) orally daily for two months. Lower urinary tract function was then assessed through urodynamic testing, including void spot assay, uroflowmetry, and anesthetized cystometry. Prostate lobes were collected for histology. This data set contains Excel sheets and raw data for void spot assay, uroflowmetry, and anesthetized cystometry. It also contains raw data for animals in the study in terms of prostate, seminal vesicle, and testes wet weights. Data for cell counts of the number of Ki67 positive cells, Caspase 3 positive cells, and smooth muscle thickness of prostate tissue are also present.  , , # Data from: PCB exposure in adult male mice reduces proliferating cells in the prostate but minimally alters voiding Dataset DOI: [10.5061/dryad.fttdz096z](https://doi.org/10.5061/dryad.fttdz096z) ## Description of the data and file structure Excel files of raw data for physiology and histology assessments in adult male C57/Bl6J mice treated with PCBs for 2 months. ### Files and variables #### File: adult_male_vsa_data.xlsx **Description:**Â Raw data generated from running void spot assays (VSA) on adult wild-type male mice treated with vehicle or 0.1, 1 or 6mg/kg/d PCBs for 2 months. For VSA mice are placed on a filter paper for 4 hours and then the filter papers containing urine spots were imaged with UV light. The resulting images were analyzed via Void Whizzard software freely available as a plugin in Image J. This Excel table is the readout of the Void Whizzard analysis of the urine content on the assay papers. Each column is the voiding parameter examined, and each row is a ..., ,