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Salt-Inducible Kinase 3 in complex with an inhibitor

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Protein Data Bank Japan2024-01-24 更新2026-04-19 收录
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Salt-Inducible Kinase 3 in complex with an inhibitor Descriptor: Serine/threonine-protein kinase SIK3, ~{N}-ethyl-4-[5-[1-(2-hydroxyethyl)pyrazol-4-yl]benzimidazol-1-yl]-2,6-dimethoxy-benzamide Authors: Flower, T.G, Leonard, P.M, Lamers, M.B.A.C, Mollat, P. Deposit date: 2023-03-29 Release date: 2024-01-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312. J.Med.Chem., 67, 2024
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2023-03-29
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