Primary data for Knouse et al. Chromosome segregation fidelity in epithelia requires tissue architecture, Cell, 2018

This dataset includes primary data from Knouse et al., Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture, Cell (2018),
https://doi.org/10.1016/j.cell.2018.07.042. This paper examined the relationship between tissue architecture and chromosome segregation fidelity. The folder Figure 2 includes three-dimensional plots of cell dimensions as published in Figure 2 and Supplemental Figure 2. These plots can be viewed as .html files and depict how cell shape varies across contexts. The folder Figure 3 includes raw movie files from live imaging of immature and mature mammary epithelial cell organoids in Matrigel. These movie files can be viewed on various imaging platforms (ie MetaMorph) and reveal increased duration of mitosis, specifically prometaphase and metaphase, in the absence of tissue architecture.

本数据集收录了Knouse等人在《细胞》杂志（2018年）发表的论文《上皮中染色体分离的忠实度依赖于组织结构》中的原始数据，论文链接为https://doi.org/10.1016/j.cell.2018.07.042。该论文探讨了组织结构与染色体分离忠实度之间的关系。文件夹“Figure 2”包含发表于图2及补充图2中的细胞尺寸的三维图。这些图形可通过.html文件查看，展现了细胞形态在不同环境下的变化。文件夹“Figure 3”包含了用于观察成熟和不成熟乳腺上皮细胞器官体在Matrigel中的活体成像的原始电影文件。这些电影文件可在多种成像平台上（如MetaMorph）进行查看，并揭示了在没有组织结构的情况下，有丝分裂的持续时间增加，特别是减数分裂的前期和中期。