PDGFRA-G680R mutant kinase domain in complex with avapritinib
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PDGFRA-G680R mutant kinase domain in complex with avapritinib Descriptor: Avapritinib, Platelet-derived growth factor receptor alpha Authors: Scrima, A, Mueller, M.P, Rauh, D. Deposit date: 2025-11-27 Release date: 2026-07-15 Last modified: 2026-08-19 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST. Nat Commun, 17, 2026
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2025-11-27
