In vivo neutralization of TGF-β and CD25 induces FoxP3 expression of PLP:OVA-pσ1-primed Th2 cells.
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aSJL/J mice were challenged s.c. with 200 µg PLP139–151 in complete Freund's adjuvant plus 200 ng PT i.p. on days 0 and 2, and were nasally dosed 14 and 7 days prior to EAE challenge with 100 µg of PLP:OVA-pσ1 or with PBS and treated as described in Fig. 5. bAverage percentages ± SD of FoxP3+CD25−CD4+ T cells as a fraction of CD4+ T cells from 3 mice per group are depicted, *, P<0.001, **, P<0.05 vs. PLP:OVA-pσ1 + anti-CD25, §, P<0.05 vs. PLP:OVA-pσ1 + anti-TGF-β ˜.
创建时间：
2010-01-14
