Human macrophages exhibit high activity to clear intracellular biovar Microtus strain of Y. pestis

human peripheral lymphocytes were infected with the full virulent strain 141 or human avirulent Microtus strain 201, and their transcriptomes were determined and compared. The most impressive finding is that robust responses of lysosome, TLR signaling and Fc?R mediated phagocytosis pathways were provoked at 2 hpi in 201- but not in 141-infected lymphocytes, suggesting that human lymphocytes might be able to constrain infection caused by strain 201 but not 141. Overall design: We used RNA-sequencing technology to analyze transcriptomic of human peripheral lymphocytes infected with the full virulent strain 141 or human avirulent Microtus strain 201, and these transcriptomes were further compared and functionally validated.