Engineered APOBEC3A deaminase for highly accurate cytosine base editing.

NIAID Data Ecosystem2026-05-01 收录

碱基编辑优化

脱靶效应评估

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP424350 数据链接链接失效反馈

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资源简介：

Evaluation of A3A-CBE variants with high activity and substantially reduced off-target activity.

创建时间：

2024-02-02

Transient in vivo base editing with no detectable RNA- and DNA off-target mutations

体内基因编辑

脱靶效应评估

RNA-programmable deaminases, known as base editors (BEs), enable precise single base conversions on genomic DNA and hold great promise for therapeutic application in patients. Recent studies, however,

NIAID Data Ecosystem150

Additional file 6 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map

转基因植物基因组

脱靶效应评估

Additional file 6. List of relevant studies and the systematic map database to answer secondary question 2.

NIAID Data Ecosystem80

SURRO-seq:massively targeted evaluation of CRISPR off-targets in cells

基因编辑

脱靶效应评估

Sensitive and high-throughput methods for evaluating CRISPR RNA-guided nucleases (RGNs) off-targets (OTs) in cells are essential for advancing RGN-based gene therapies. Here we report a method for sim

DataCite Commons2022-02-21 更新70

Base editing improvement

碱基编辑优化

RNA脱靶

We examined the off-targets of new base editing tools at RNA level Overall design: cells transfected with different base editing tools or GFP were cultured for 48 hours and total RNA was purified for

NIAID Data Ecosystem100

The global impact of gene editing on the structure of the human genome

基因组编辑安全性评估

脱靶效应评估

The study evaluates the off-target effect of various currently used genome editing techniques that can potentially cause large structural changes in the human genome.

NIAID Data Ecosystem80

Engineered APOBEC3A deaminase for highly accurate cytosine base editing.

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