Methylation_profiles_in_cancer_induced_mouse_liver_tumours

Human cancers arise through the combined effect of environmental exposures and endogenous mutagenesis resulting from factors such as replication stress and metabolism. Here, we will address the question of how exposure to a wide variety of exogenous agents can shape epigenomic architecture. Specifically, we will characterize the methylation profiles of dozens of suspected/known human carcinogens used to induce hundreds of mouse liver tumours and then explore the changes of the methylation profiles following carcinogen exposure. Other aspects of tumour biology will also be explored, such as mutational signatures, driver genes, and the effect that carcinogens have on the copy number landscape and profile of structural variants found in tumours.