Spatial transcriptional profiling to define transcriptional changes of the brain under oxdative stress

Oxidative stress is demonstrated to play an important role in the etiology of neurodegenerative diseases. In order to defense against oxidative stress, organisms possess glutathione as an important antioxidant. However, glutathione level is decreased with ageing and progression of diseases. To elucidate the relationship between pathological changes and transcriptional changes under glutathione reduction-mediated oxidative stress in the brain, we performed the spatial transcriptomic profiling of the brains of gclc (catalytic subunit of glutamyl cysteine ligase) knockout mice.