Altering sphingolipid metabolism attenuates cell death and inflammatory response after myocardial infarction
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
We performed transcriptomic analyses to evaluate changes in gene expression post MI. We investigated the effect of ACmodRNA function post MI. We found that several genes involved in de novo ceramide synthesis were upregulated. ACmodRNA treatment increased cell survival postMI. AC modRNA-treated mice had significantly better heart function, long term survival and smaller scar size than control mice 28 days post MI.
提供机构：
Icahn School of Medicine at Mount Sinai
创建时间：
2022-02-20
