The prebuilt database for NIRA (Network inference and cell type Identification by integrating scRNA-seq with ATAC-seq)

As chromatin accessibility provides rich information on transcription factor binding process, for a given TF-based raw regulon, firstly we test whether the TF motif is enriched in this regulon. To perform this efficiently, we have built our own database in BED format, which contains all available TF motifs and their occurrences across the potential binding regions (TSS$\pm10$ kb) of all MOUSE genes.

染色质可及性提供了关于转录因子结合过程的丰富信息。针对基于特定转录因子的原始调控子，首先我们检验该调控子中转录因子基序是否富集。为了高效执行此操作，我们构建了自己的数据库，该数据库采用BED格式，其中包含了所有可用的转录因子基序及其在所有小鼠基因潜在结合区域（TSS±10 kb）中的出现情况。