Structural comparison of different NMP kinases.

Ribbon diagrams of CMPK (a), UMPK (b) and AMPK (c). For comparison, the individual domains are consistently colored: CORE-domain (blue), NMP-domain (green), LID-domain (yellow). The long insert of CMPK (orange) significantly increases the surface between CORE and NMP-domain. The single cis-proline of each protein is colored in red. While the position of this residue within a flexible region is conserved between UMPK and AMPK, it is shifted to a hinge-region in case of CMPK.