Intellicage analysis of Cpa3+/+ and Cpa3Cre mice

We investigated antigen-specific avoidance behavior in mice, and found that is critically dependent on mast cells. We interrogated potential signaling routes between mast cells and the brain using mutant mice, pharmacological inhibition of serotonin receptor 3, neural activity recordings, and vagotomy. We analyzed gene expression comparing naive versus immunized wild type mice, and versus mast cell-deficient mice at different times following antigen exposure Comparative gene expression profiling analysis of RNA-seq data for Cpa3+/+ (wild type) and Cpa3Cre/+ (mast cell-deficient) mice