aRes: atomic resolution of the protein structure in Å. bShape String: shape identified by PoreWalker, going from the lowest to the highest coordinate along the pore axis. D, U and S indicate decreasin
Additional file 1. COSNeti python module USAGE.md file for the integration of relative changes obtained by omics-technologies into Cryo-EM or crystallography based randomly sampled interaction network
The enzyme was preincubated for 5 min at 35°C with the various reagents before addition of the substrate. Each reagent was added at the final concentration as indicated.
