How does the complex 3D structure of tendons emerge over development?
收藏ESRF Portal2028-01-01 更新2026-04-23 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-ES-2066449146
下载链接
链接失效反馈官方服务：
资源简介：
Tendons have an extraordinary ability to withstand loads due to their unique multi-scale complex hierarchical organization, where the collagen molecule is the basic building block. Collagen is arranged in different structural units (fibrils and fibers and fascicles) up to the organ level, which are known to stretch, slide and move relative to each other during loading. What is still not known is how the structure of the tendon emerges and develops from birth to adulthood. In this proposal, we would like to use phase contrast tomography to image tendons from the goat ranging from neonates to adult, to unravel how the different sub-units, e.g. fascicles, develop, and how the collagen fiber distribution emerges. We need to use a large animal model, as smaller animals do not have all the same structural units as humans, and this can affect the interpretation of the results. Therefore, we are applying to BM18.
提供机构：
Lund University, Biomedical Engineering / Biomechanics, Box 118, 22100, Lund, SE; University College Dublin, School of Mechanical and Materials Engineerin, Stillorgan Rd, Belfield, D04 V1W8, Dublin, IRELAND; Lund University, Department of Biomedical Engineering, Klinikgatan 32, 22184, Lund, SE
创建时间：
2028-01-01
