Rosiridin reduces Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a highly lethal, difficult-to-treat, and progressive disease characterized by the massive transformation of lung fibroblasts into myofibroblasts, proliferation of the extracellular matrix (ECM), increased collagen deposition, and damage to lung structure and function. Rosiridin is a monomeric compound isolated from Rhodiola rosea. However, whether rosiridin has a protective effect on bleomycin induced idiopathic pulmonary fibrosis and its mechanism remain to be elucidated. Our aim was to investigate the role and mechanism of rosiridin in idiopathic pulmonary fibrosis.