Crystal structure of insulin degrading enzyme complexed with inhibitor
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Crystal structure of insulin degrading enzyme complexed with inhibitor Descriptor: Insulin-degrading enzyme, ZINC ION, methyl [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate Authors: Wang, Y, Guo, S. Deposit date: 2014-04-28 Release date: 2015-06-17 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J.Biol.Chem., 290, 2015
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2014-04-28
