GRCh38-based LD Score Regression (LDSC) LDscore files and weight files from 1000 Genomes EUR Phase 3

This resource provides LD Score Regression (LDSC)-relevant LD score files and regression weight files based on the 1000 Genomes Project Phase 3 European (EUR) reference panel aligned to the GRCh38/hg38 genome assembly. All variants were harmonized to the GRCh38 reference genome and represented using the standardized variant identifier format: CHR:POS:REF:ALT (This allele-aware representation is more compatible with modern sequencing-based GWAS analyses, particularly whole-genome sequencing (WGS)-based studies, where precise reference and alternate allele definitions are essential for variant harmonization and cross-study integration.) The final reference variant set contains: 1,189,035 HapMap3 variants excluding the MHC region. The released files include: - GRCh38-version HapMap3 no-MHC variant list - Chromosome-specific LD score files for chromosomes 1–22 - Chromosome-specific LDSC regression weight files for chromosomes 1–22 Scripts used for resource generation are publicly available at: https://github.com/shiyuzhang0522/LDSC-GRCh38-Based-Resources This resource is intended for researchers performing LDSC analyses using GRCh38-based GWAS summary statistics. For questions, suggestions, or issues regarding this resource, please contact: Shiyu Zhang (Email: [e-mail])