Crystal structure of PRMT5:MEP50 in complex with PRT543

Crystal structure of PRMT5:MEP50 in complex with PRT543 Descriptor: 1,2-ETHANEDIOL, 7-[(3xi,5R)-5-C-(3,4-dichlorophenyl)-3-C-methyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein WDR77, ... Authors: Leal, R.A, Pitis, P.M, Dou, Y, Lin, H, Wang, M, Xu, C. Deposit date: 2024-09-18 Release date: 2025-02-12 Last modified: 2025-03-19 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Phase Ib study of PRT543, an oral protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced splicing factor-mutant myeloid malignancies. Leukemia, 39, 2025