The Durability of Twice-Daily Insulin Lispro Low Mixture Compared to Once-Daily Insulin Glargine When Added to Existing Oral Therapy in Patients With Type 2 Diabetes and Inadequate Glycemic Control

This study will compare insulin lispro low mixture [LM] and insulin glargine both in
combination with the patient's oral diabetes medicines, for their ability to control blood
sugar in patients with type 2 diabetes and compare insulin lispro LM to insulin glargine with
regard to the length of time that the overall blood sugar can be controlled.

This study will also determine whether the safety of insulin lispro LM and any side effects
that might be associated with it are different from those observed with insulin glargine,
both in combination with the patient's oral diabetes medications.

The addendum study (Intensification Addendum) will compare how different insulin treatments
work to control blood sugar in patients whose diabetes could not be controlled by either
insulin lispro LM or insulin glargine.