The loss of a single chromosome in a diploid organism halves the dosage of many genes and is usually accompanied by a substantial decrease in fitness. We asked whether this decrease simply reflects th
Systemic lupus erythematosus (SLE) is a severe autoimmune disease that displays considerable heterogeneity not only in its symptoms, but also in its environmental and genetic causes. Studies in SLE pa
Maximun and minimun values for each average epistatic coefficient ( ) evaluated over an ensemble encompassing 15 networks, categorized as either arbitrary or functional. ANC: XTR indicates arbitrary n
Characterization of the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms. Here
