BIOGRID CURATED DATA FOR MUK1 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for MUK1 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Guanine nucleotide exchange factor (GEF); involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF VPS9; required for localization of the CORVET complex to endosomes; contains a VPS9 domain

由 BioGRID (https://thebiogrid.org) 精心整理的 MUK1（酿酒酵母 S288c）蛋白-蛋白、遗传和化学相互作用数据集；定义：鸟苷酸核苷酸交换因子（GEF），参与囊泡介导的溶酶体运输，包括高尔基体-内质网转运及通过多泡体（MVB）的分离；特异性刺激 Rab 家族成员（Vps21p/Ypt52p/Ypt53p）的内源性鸟苷酸核苷酸交换活性；部分与 GEF VPS9 具有冗余性；对于 CORVET 复合体定位到内体至关重要；包含 VPS9 结构域。