Gene expression data for SARS-CoV-2 infection of IBD intestinal organoids

Figshare2026-01-28 更新2026-04-28 收录

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https://figshare.com/articles/dataset/Gene_expression_data_for_SARS-CoV-2_infection_of_IBD_intestinal_organoids/31173634 数据链接链接失效反馈

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资源简介：

Reduced SARS-CoV-2 infection levels and pathotype specific altered antiviral transcriptional response in IBD intestinal organoids.

创建时间：

2026-01-28

Transcriptome analysis of human colonic organoids infected SARS-CoV-2

类器官感染模型

宿主-病毒转录组学

Purpose: To identify the diferentially expressed genes in SARS-CoV-2 susceptible and resistant organoids during the ifnection. Method: We selected 3 susceptible (C8, C9, and C10)- and 3 restant (C1, C

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HNF4a acts as upstream functional regulator of intestinal Wnt3 and Paneth cell fate [RNA-seq]

肠道类器官

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Maturation of Paneth cells depends on canonical Wnt signaling, but few transcriptional regulators have been identified to this end. We showed that HNF4a plays a non-redundant and crucial role in suppo

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Viral infection of human neurons triggers strain-specific differences in host neuronal and viral transcriptomes

神经病学

宿主-病毒转录组学

Infection with herpes simplex virus 1 (HSV-1) occurs in over half the global population, causing recurrent orofacial and/or genital lesions. Individual strains of HSV-1 demonstrate differences in neur

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SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial Cells. SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial Cells

病毒免疫逃逸

宿主-病毒转录组学

Here we report differential regulation of innate immune response by SARS-CoV-2 variants and immune antagonism by Alpha and Delta variant. Overall design: Caco-2 cells were infected with four different

NIAID Data Ecosystem90

Analysis of the transcriptomic changes in murine small and large intestinal organoids after the sudden expression of BRAFV600E and/or p53R172H. Analysis of the transcriptomic changes in murine small and large intestinal organoids after the sudden expression of BRAFV600E and/or p53R172H

癌基因转录组学

肠道类器官

BRAFV600E confers poor prognosis and a distinct molecular type of colorectal cancer, which is often associated with TP53 alterations. In order to understand how BRAFV600E and p53R172H promote tumorige

NIAID Data Ecosystem80

Gene expression data for SARS-CoV-2 infection of IBD intestinal organoids

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