Stereochemical accuracy and geometry of the structures and models used in the study.

The Excel file contains the results of the analysis by the MolProbity server. The output of the server is provided for three stages of model optimization: structures with the atom coordinates identical to the experimental structure (Original), structures after adding all missing atoms in partially resolved residues but lacking the missing regions (Completed), and structures with completed missing regions and minimized model energy (Optimized). “Segments for MIB2 analysis” – structures used for the analysis of divalent ion binding to the EF-hand region (20 structures). “Core dimers for OHM analysis” – structures used for the analysis of allosteric pathways by the OHM server (9 structures). (XLSX)