Enantioselective Direct Mannich Reactions of Cyclic β‑Ketoesters Catalyzed by Chiral Phosphine via a Novel Dual-Reagent Catalysis
收藏NIAID Data Ecosystem2026-03-07 收录
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A combination of an amino acid derived chiral phosphine catalyst and methyl acrylate efficiently catalyzed the direct Mannich reaction of cyclic β-ketoesters and N-Boc-aldimines. The dual-reagent catalysis was presumed to function through the formation of a zwitterion, which catalyzed the reaction with excellent stereocontrol via a hydrogen-bonding assisted chiral ion-pair pathway.
创建时间：
2016-02-15
