Derivatization of Preformed Platinum N‑Heterocyclic Carbene Complexes with Amino Acid and Peptide Ligands and Cytotoxic Activities toward Human Cancer Cells
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https://figshare.com/articles/dataset/Derivatization_of_Preformed_Platinum_N_Heterocyclic_Carbene_Complexes_with_Amino_Acid_and_Peptide_Ligands_and_Cytotoxic_Activities_toward_Human_Cancer_Cells/2470366
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资源简介：
A simple procedure for the preparation of N-heterocyclic
carbene
platinum complexes with a nitrogen-based neutral ligand in trans geometry is presented. The lability of a trans pyridine ligand in an N-heterocyclic carbene–Pt(II)–pyridine
complex, namely, (3-benzyl-1-methylimidazolylidene)PtI2(pyridine), 2, was probed by a displacement reaction
with various nitrogen-based ligands (e.g., amines, hydrazine, amino
esters, and peptides) to yield the corresponding complexes, which
could be easily isolated by column chromatography. Two representative
complexes could be characterized by X-ray crystallographic studies.
This strategy allows generating diversity in metallodrug candidates.
Preliminary results of the biological effects on various human cancer
cells and comparison wih cisplatin are reported.
创建时间：
2016-02-20
