DNAmod

Covalent DNA modifications have been found in numerous organisms and more are continually being discovered and characterized, as detection methods improve. Many of these modifications can affect the conformation of the DNA double helix, often resulting in downstream effects upon transcription factor binding. Some of these modifications have been demonstrated to be stable, while others are viewed as merely transient. DNAmod catalogues information on known DNA modifications, of which the well-known 5-methylcytosine is only one. It aims to profile modifications' properties, building upon data contained within the Chemical Entities of Biological Interest (ChEBI) database. It also provides literature citations and includes curated annotations on mapping techniques and natural occurrence information.

共价DNA修饰已在多种生物体中发现，并且随着检测方法的进步，不断有新的修饰被发现并得到表征。众多此类修饰能够影响DNA双螺旋结构的构象，通常导致转录因子结合的下游效应。其中一些修饰已被证明是稳定的，而另一些则被视为仅是瞬时的。DNAmod目录收录了已知DNA修饰的信息，其中广为人知的5-甲基胞嘧啶只是其中之一。它旨在描述修饰的性质，并基于化学生物兴趣实体（ChEBI）数据库中的数据构建。此外，它还提供了文献引用，并包含了对映射技术和自然发生信息的精心注释。