Sequence alignment of segment 126-204 from the second Ig-like domain of the CD4 molecule from different primate species.

Sequences (amino-acids 126 to 204) were obtained from UniProt under the following accession numbers: Homo sapiens (P01730), Papio anubis (C1JYS8 and B1NC12), Macaca nemestrina (Q08340), Pan troglodytes (P16004), Macaca mulatta (P16003), Macaca fascicularis (P79185). The underlined sequences indicate the two synthetic peptides used for epitope mapping. Alignment was performed using the T-COFFEE software (version 1.41) and with the Nomad (Neighborhood Optimization for Multiple Alignment Discovery) program. Asterisks indicate identity; colons indicate homology. Positions with non-conservative substitutions between human and nonhuman primate sequences are in bold.