M1: fraction of green fluorescence (IL15 or IL15Rα) overlapping with red fluorescence (EEA or Rab7). M2: fraction of red fluorescence (EEA or Rab7) overlapping with green fluorescence (IL15 or IL15Rα)

NIAID Data Ecosystem60

Identification of Discrete Classes of Endosome-derived Small Vesicles as a Major Cellular Pool for Recycling Membrane Proteins

内体

蛋白回收机制

Vesicles carrying recycling plasma membrane proteins from early endosomes have not yet been characterized. Using Chinese hamster ovary cells transfected with the facilitative glucose transporter, GLUT

PubMed Central30

A molecular view on the escape of lipoplexed DNA from the endosome (no trajectories)

非病毒载体基因递送

内体

The use of non-viral vectors for in vivo gene therapy could drastically increase safety, whilst reducing the cost of preparing the vectors. A promising approach to non-viral vectors makes use of DNA/c

NIAID Data Ecosystem70

Proteomic Analysis of Src Family Kinases Signaling Complexes in Golgi/Endosomal Fractions Using a Site-Selective Anti-Phosphotyrosine Antibody: Identification of LRP1-Insulin Receptor Complexes

胰岛素信号传导

内体

A role for Src Family Kinases (SFKs) in the dynamics of endocytic and secretory pathways has previously been reported. Identification of low-abundance compartmentalized complexes still remains challen

NIAID Data Ecosystem30

Rapid in-vivo endosomal escape assay reveals insights into mechanism of efficient lipid nanoparticle-based RNA delivery

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