Mlycd deficiency in Dahl salt-sensitive rats

Mlycd (malonyl-CoA decarboxylase) is a regulator of fatty acid metabolism. Lysine supplementation depletes kidney malonyl-CoA in hypertensive Dahl SS rats. As a key regulatory mechanism, lysine malonylation influences mitochondrial enzymes and fatty acid metabolism, with implications for CKD, hypertension, and other disorders. Yet how the balance between malonylation and acetylation is altered, and how this affects salt-sensitive hypertension, remains unclear. In this study, we examined the proteomic and metabolomic alterations resulting from Mlycd deficiency in Dahl salt-sensitive rats. This dataset contains proteomic profiles of heart, kidney, liver tissues as well as plasma and urine samples obtained from both Mlycd+/+ and Mlycd+/- animals.