Effects of cooperative DNA binding by the primary TF and a secondary TF (“M2”), that were significant at distance threshold either 30 bp or 150 bp.

Only cases involving secondary motifs other than “VFL” and “TRL”, and where P-value≤0.05 and Z-score ≥3 are shown here. Cases where the improvement at distance threshold 30 bp was similar to or better than that at 150 bp are highlighted in bold. Dashes indicate that the secondary motif was not observed to show significant improvement at the specific distance threshold. This table presents results from testing all secondary motifs whose TFs were in the top 25% most highly expressed TF genes (out of the ∼300 TF genes with motifs) in the appropriate developmental stage. This is contrast to other tables (2, 3, 4, 6), where the tested secondary motifs correspond to TFs that are in the top 10–15% most highly expressed TF genes for the stage. In this table, the rows marked with asterisks correspond to secondary TFs in the top 10–15% most highly expressed TF genes.