Host genetics shapes the recovery of the gut microbiome after antibiotic treatment: The role of the blood group related B4galnt2 gene

Host genetics can influence gut microbiota recovery following antibiotic disruption. We investigated the role of the B4galnt2 glycosyltransferase gene in modulating post-antibiotic microbiota restoration in mice. Using a longitudinal, multi-omic approach integrating 16S rRNA sequencing, metagenomics, and metatranscriptomics, we compared microbiota dynamics in B4galnt2+/– and B4galnt2–/– mice treated with streptomycin, kanamycin, and vancomycin. This study provides insight into genotype-dependent microbiota recovery and underscores the role of host glycosylation in shaping microbial resilience after antibiotic exposure.