Crystal Structure of human IDO1 bound to Compound 23
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Crystal Structure of human IDO1 bound to Compound 23 Descriptor: (1R,2S)-8-(ethanesulfonyl)-2-[(4R,5S,9aM)-5H-imidazo[5,1-a]isoindol-5-yl]-8-azaspiro[4.5]decan-1-ol, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE Authors: Steinbacher, S, Lammens, A, Harris, S.F. Deposit date: 2023-09-12 Release date: 2024-11-27 Last modified: 2026-08-12 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Exploiting Stereo-Complexity to Identify Spirocyclic Imidazoisoindoles as Potent and Orally Bioavailable Dual Inhibitors of Indoleamine-2,3-Dioxygenase and Tryptophan-2,3-Dioxygenase To Be Published
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2023-09-12
