Pharmacokinetic parameters of indinavir (40 mg/kg orally) after multiple dosage.
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The rats received oral administration of indinavir (40 mg/kg) together with 1.5% Tween 80 (vehicle), Sophora extract (0.158 g/kg or 0.63 g/kg), Oxymatrine capsule (45 mg/kg of oxymatrine equivalent), or ethyl acetate (EA) fraction of Sophora extract (0.082 g/kg), twice a day for 7 days, respectively. On the experimental day (day 8), animals were pretreated with corresponding vehicle or tested drugs at 1 h prior to the last dose of indinavir given to all rats for pharmacokinetic study. Values are expressed as mean ± S.E.M. (n = 6–9). Significance is indicated as*P**P***P
创建时间：
2015-12-02
