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Malaria-parasite survival of host fever is linked to artemisinin resistance

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NIAID Data Ecosystem2026-03-12 收录
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RNAseq data profiling two heatshock-sensitive P. falciparum piggyBac mutants with and without exposure to febrile temperatures. Each run-folder contains paired-end fastq data for two complete bioreps of the three parasite lines (NF54 wild-type control; heatshock-sensitive mutants {delta}DHC and {delta}LRR5--referred to in sample-names as PB4 and PB31, respectively) collected after 8 hours with or without exposure to febrile temperatures (41C and 37C, respectively). All parasites were at ring-stage at point of harvest as verified by Giemsa-stained microscopy. Each sample was run twice on an Illumina Miseq--the second run using total reads for each sample from the first run to inform concentration needed for each sample in run2 to ensure equal coverage of all samples.

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2021-08-11
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