Comparison of Gut Microbiota in IBS Rat Model

Various animal models have been developed to study the underlying mechanisms of IBS and it was suggested that the alterations in the gut microbiota plays important role in the development of IBS. The aims of this study was to identify the influence of modeling procedures on bacterial communities and investigate whether different modeling procedures lead to consistent patterns of gut microbiota compositions. Two IBS rat models (MS alone and multiple-early-adversity modeling) were established and the microbiota compositions of colon contents were analyzed using 16S-rRNA-based high-throughput sequencing methods.