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Crystal structure of TFPI K2 domain in complex with 4D8 Fab fragment

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Protein Data Bank Japan2026-06-17 更新2026-06-20 收录
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Crystal structure of TFPI K2 domain in complex with 4D8 Fab fragment Descriptor: 4D8 Heavy chain, 4D8 Light chain, Tissue factor pathway inhibitor Authors: Juo, Z.S, Mosyak, L. Deposit date: 2026-05-18 Release date: 2026-05-27 Last modified: 2026-06-17 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Discovery and optimization of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor for the treatment of hemophilia A and B. Mabs, 18, 2026

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2026-05-18
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