A4GALT transfers galactose to LacCer

Lactosylceramide 4-alpha-galactosyltransferase (globotriaosylceramide (Gb3)/CD77 synthase, A4GALT) transfers a D-alpha-galactose moiety from UDP-alpha-D-galactose onto the 4-position of the beta-galactose residue of lactosylceramide (LacCer) to produce globoside (Gb3Cer). The reaction starts the biosynthesis of globo series glycolipids, which are present on erythrocytes, forming the P1PK blood group system, and may play a role in cancer of other tissues (Kojima et al., 2000; Iwamura et al., 2003).

乳糖鞘氨醇4-半乳糖基转移酶（globotriaosylceramide（Gb3）/CD77合成酶，A4GALT）将UDP-α-D-半乳糖的D-α-半乳糖基团转移至乳糖鞘氨醇（LacCer）的β-半乳糖残基的4位，以产生.globoside（Gb3Cer）。该反应启动了globos系列糖脂的生物合成，这些糖脂存在于红细胞上，形成P1PK血型系统，并可能在其他组织的癌症中发挥作用（Kojima等，2000；Iwamura等，2003）。