Examples of circRNA isoform switches between sAD and control in frontal lobe synaptosomes.

Comparing RNA sequencing data mapped to circRNA back-splice junctions between AD and control synaptosomes revealed that significant expression changes often arose from multiple circular isoforms originating from the same gene and would show contrasting fold changes. “Donor” refers to the downstream exon by which its 3′ end is spliced back onto the upstream “Acceptor” exon’s 5′ end. We report the raw p value.