Human Protein Atlas - Pathology Atlas

The Pathology Atlas contains mRNA and protein expression data from 17 different forms of human cancer. Correlation analyses based on mRNA expression levels of human genes in cancer tissue and the clinical outcome for almost 8000 cancer patients is presented in a gene-centric manner, including more than 18000 Kaplan-Meier plots with high significance (p<0.001). Analysis of each protein and its corresponding cancer type in patients, using immunohistochemistry (IHC) analysis based on tissue microarrays (TMAs), is presented for a majority of the protein-coding genes. The resulting 5 million IHC cancer tissue images are presented here. All transcriptomics data has been retrieved from the Cancer Genome Atlas and all proteomics data has been generated in-house using the same antibodies as in protein expression profiling in normal human tissues. Cancer statistics from relevant international and Swedish databases are summarized here, and hallmarks of cancer are described here.

病理图谱收录了17种不同类型的人类癌症的mRNA和蛋白质表达数据。本图谱以基因为中心，展示了基于癌症组织中人类基因mRNA表达水平与近8000名癌症患者临床结果的相关性分析，其中包括超过18000个具有高度显著性（p<0.001）的Kaplan-Meier生存曲线。对于大多数编码蛋白质及其对应的癌症类型，通过基于组织微阵列（TMAs）的免疫组织化学（IHC）分析，展示了每个蛋白质的分析结果。图谱中呈现了500万张IHC癌症组织图像。所有转录组数据均来自癌症基因组图谱，所有蛋白质组数据均采用与正常人类组织蛋白质表达分析相同的抗体自行生成。此外，还总结了来自相关国际和瑞典数据库的癌症统计数据，并描述了癌症的特征。