Class I homeobox (Hox) genes encode a major group of transcription factors controlling embryonic development and have been implicated in the continuing process of hematopoietic cell differentiation. T

PubMed Central1994-12-06 更新40

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [TargetedCRISPRscreen]

白血病发病机制

CRISPRi筛选

Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe

NIAID Data Ecosystem30

Total RNA sequencing for Mus musculus bone marrow lymphoid committed cell populations

细胞RNA测序

造血干细胞

MPP2, MPP3 and CLP populations were isolated by fluorescence-activated cell sorting (FACS) from the BM of B6 mice based on the surface expression of VCAM1, FLT3 and IL7Ra within LSK population. On a

NIAID Data Ecosystem40

Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions. Mus musculus

造血干细胞

系统发育

To identify the molecular characterisitics of parallel lineage-biased MPP populations arising from hematopoietic stem cells (HSC) we conducted genome-wide analyses of hematopoietic stem, progenitor an

NIAID Data Ecosystem40

Transduced cord blood CD34+ cells with empty vector, AML1-ETO and ETV6-RUNX1

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