Human Embryonic Stem Cell Spheroids exosomal miR-6766-3p alleviate activation of hepatic stellate cells and liver fibrosis by targeting TGFβRII in CCl4-induced liver fibrosis

To further explore the gene expression between 2D-hESCs-Exosomes and 3D-hESCs-Exosomes, we have employed MiRNA microarray expression profiling as a discovery platform to identify. To screen and identify the candidate miRNAs in 3D-hESCs-Exosomes that enhanced the antifibrotic efficacy of 2D-hESCs-Exosomes in CCL4-induced fibrosis, a miRNA microarray was used to profile the simultaneously upregulated or downregulated miRNAs between 2D-hESCs-Exosomes and 3D-hESCs-Exosomes.