HaptenDB: A database for maintaing information on hapten molecules

Welcome to the official documentation for HaptenDB, a specialized curated database designed to facilitate the development of successful immunochemical assays. HaptenDB provides a centralized resource for information on small molecules (haptens), the carrier proteins they are conjugated to, and the resulting anti-hapten antibodies. Web Server: http://crdd.osdd.net/raghava/haptendb/(https://webs.iiitd.edu.in/raghava/haptendb) Citation Singh, M. K., Srivastava, S., Raghava, G. P. S., & Varshney, G. C. (2006). HaptenDB: a comprehensive database of haptens, carrier proteins and anti-hapten antibodies. Bioinformatics, 22(2), 253–255. https://doi.org/10.1093/bioinformatics/bti692. GitHub:- https://github.com/Manish-IIITD-repository/HaptenDB About the Platform Small molecules, such as haptens, are not immunogenic on their own but can elicit an antibody response when conjugated with a carrier molecule. The production of high-specificity anti-hapten antibodies depends on hapten design, selection of the carrier protein, and the conjugation method. HaptenDB compiles this scattered information from published literature and web resources into a structured, easily accessible format. Database Statistics Haptens: Detailed information for 1,087 unique haptens. Carrier Proteins: Data for 25 different carrier proteins used in conjugation. Total Entries: Over 2,021 comprehensive entries providing chemical and immunological details. Key Features Search and Query Tools Simple Search: Quick retrieval based on hapten name, category, or carrier protein. Advanced Search: Complex multi-field querying using logical operators (AND/OR) to filter by specific chemical or experimental parameters. Browsing: Users can browse the database by hapten category, carrier protein type, or alphabetical order. Comprehensive Annotations Chemical Data: Information on molecular weight, chemical formula, and structure for each hapten. Conjugation Details: Details on the method of conjugation, site of attachment, and linkers used. Antibody Data: Information on the specificity and affinity of the resulting anti-hapten antibodies. Technical Overview HaptenDB is implemented using a robust architecture to ensure efficient data management and a user-friendly experience. Backend: Managed with a MySQL database for organized data storage. Web Interface: Developed using PHP and HTML to provide a responsive and easy-to-navigate platform. External Links: Entries are cross-referenced with resources such as PubMed and the Kabat database. Applications Assay Development: Assisting in the design of specific haptens and selecting appropriate carrier proteins for antibody production. Environmental Monitoring: Providing data on antibodies used to detect pesticides and herbicides. Research: Serving as a high-quality resource for structure-activity relationship studies of hapten-antibody interactions. Contact & Authors Grish C. Varshney & G.P.S. Raghava Institute of Microbial Technology, Chandigarh, India.Email: [e-mail] / [e-mail] License This resource is open-access and distributed under standard research terms, permitting use and distribution provided the original work is properly credited.