Catalytic Enantioselective House–Meinwald Rearrangement: Efficient Construction of All-Carbon Quaternary Stereocenters
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
A catalytic asymmetric House–Meinwald rearrangement for the synthesis of both cyclic and acyclic ketones is disclosed. From readily accessible racemic tetrasubstituted epoxides, this approach provides efficient access to chiral ketones bearing α all-carbon quaternary stereocenters with high enantiocontrol. The observation of positive nonlinear effects and nontrivial kinetic feature provided important insights into the mechanism.
创建时间：
2019-08-20
