Salivary microbiome analysis of severe early childhood caries

severe early childhood caries (SECC) is a bacterial inflammatory disease with complex pathology. Although changes in the oral microbiota and metabolic profile of patients with ECC have been identified, the salivary metabolites and the relationship of host-bacterial interactions with biochemical metabolism remain unclear. We aimed to analyse alterations in the salivary microbiome and metabolome of children with SECC as well as their correlations. Accordingly, we aimed to explore potential salivary biomarkers in order to gain further insight into the pathophysiology of dental caries.