Metabolic reprogramming in livers from LKB1 KO mice

The goals of this study was to compare hepatic transcriptome profiling (RNA-seq) in wild type (WT) and Liver Kinase B1 knock out (LKB1 KO) mice Methods: hepatocyte mRNA profiles of 10-weeks-old WT and LKB1 KO mice were generated, in triplicate, using Illumina NextSeq technology. The sequence reads that passed quality filters were analyzed at the gene level. Overall design: Three 6 weeks old wild type (WT) and 3 LKB1 fl/fl mice were injected with AAV8 Cre. Livers were harvested for analysis 4 weeks after.