The long noncoding RNAs and mRNAs in the hepatocellular carcinoma at early and intermediate stage

Recently, long noncoding rnas (lncRNAs) have been shown to have key roles in the development and prgression of hepatocellular carcinoma (HCC). However, the mechanism that contributes to the HCC biology is unknown, especially at the early and middle stages. In this study, we comprehensively investigaged lnRNAs and mRNAs expression in HCC. We found three significant lnRNAs for diagostic markers in HCC at early stage. A ten chip study using total RNA recovered from five HCC tissues and corresponding five HCC adjacent normal tissues